What You Need to Know About Stem Cells

plastic surgery dr paul howardResearchers and even medical students have known about stem cells for decades. They are the multi-potential cells in embryos that can become any cell in the body; brain, muscle, heart, etc. Years later an adult version of the stem cell was identified, not quite as basic as the embryonic stem cells, but able to become many other types of cells.

Once identified, we could grow them outside the body and stimulate them to become more advanced cells such as those composing cartilage, muscle, bone and even heart tissue.

More recently it was discovered that the bodies’ main repository of adult stem cells is in our fat (adipose) tissue. These adult stem cells can also be harvested from the bone marrow in much smaller quantities and with significantly greater pain.

This discovery was great for plastic surgeons as we are the primary surgeons who harvest fat for cosmetic reasons by suction-assisted lipectomy (liposuction). With this technique, liters of fat can be harvested at one time to be processed to release the adult adipose-derived stem cells from the fat.

There are methods that currently exist to multiply the number of stem cells from thousands to hundreds of millions, but this must be done in a laboratory and is controlled by the FDA.

These stem cells once multiplied and stimulated in the lab can become a medical treatment by replacing injured or worn out cells in the heart, joints and maybe even other organs such as the liver and kidney.

For the present, we can use a person’s own stem cells (not Aunt Thelma’s) to replace soft tissues if injured using your very own fat cells which already are charged with stem cells. Fat grafting to the face as part of a facial rejuvenation procedure has been around a decade or so in my practice. The addition of extra stem cells to the facial fat grafting we do with facelifts gives a remarkable improvement in skin tone and texture due to the rejuvenating qualities of stem cells.

The limit to stem cells is that they only work for you because you and your stem cells have the same DNA. Therefore, one can harvest and freeze your fat with your stem cells for future use but no one can “borrow” your stem cells.

Another limitation to stem cell medicine is that you cannot rub stem cells on your skin like sun block. The stem cells only work inside your body where they can interact with other cells. It naturally follows that if you cannot use Aunt Thelma’s stem cells, stem cells from other DNA sources like plants and trees have no effect on humans but are probably great for other plants and trees.

Just the words “stem cells” have become a cultural phenomenon. I’ve read recently where stem cells can reconstruct a breast and even make a small breast larger. Of course, none of that is true but fat grafting, with or without stem cells, is commonly used to reconstruct soft tissue defects of the face, breast and buttocks. The stem cells are there just to improve the amount of fat that survives with grafting and provide no volume on their own.

Advertisers who use the words “stem cells” to describe their latest, greatest fountain of youth product are taking advantage of the hyperbole of public perception which is totally different from the public facts regarding stem cells.

Which are better: Bone Marrow or Adipose Derived Stem Cells?

In the race from body to petri dish Bone Marrow Stem Cells (BMSC) has been the standard bearer among research scientists since their discovery in the 1960’s. They have the advantage of being well-known and easily understood by researchers. The primary downside to BMSCs from the beginning has been the clinical difficulty harvesting the cells from bone marrow derived from the pelvis of the donor. This bone marrow harvesting procedure generally requires general anesthesia and is painfully difficult for the patient.

Embryonic Stem Cells, when available, were the preferred choice of many doctors until the philosophical question of the beginning of life was raised and left unanswered. The utilization of human fetuses and umbilical cords for the purpose of research has been banned in the U.S. for several years.

Adipose Stem Cells (ASC), a more recent discovery, have been shown to be easily harvested by modern techniques of liposuction with very little pain or discomfort. Liposuction is a simple office procedure without the need for general anesthesia and provides the donor with a cosmetic improvement as a secondary consequence to the attainment of large quantities of ASCs.

ASCs, besides being easy to harvest, have been shown to have 100-500 times more stem cells than an equal volume of bone marrow. When intended for immediate use, the Stromal Vascular Fraction (SVF) of the centrifuged fat contains all of the stem cells and can be used interchangeably with the isolated, cultured adipose stem cell product.

There is an increasing amount of research in the field of restorative medicine, so we are working with the Adicyte Company to harvest and make available to our patients at a future date their own adipose stem cells harvested today by liposuction. In the near future when research has become sophisticated enough to offer treatments based on autologous stem cells, your stem cells can be retrieved, thawed out and used for stem cell therapy as if they were brand new. Current therapies currently under protocol include re-growing cardiac muscle after heart attack, treating autoimmune and immunological diseases and re-growth of cartilage in damaged knees and shoulders. There is even some preliminary work in a treatment for certain cancers also.

Dr. Paul Howard now offers stem cell storage with your adipose tissue (fat) – learn more